Keratoconus is characterized by the thinning of the cornea and irregularities of the cornea’s surface. The cornea is the clear, outer layer at the front of your eye. The middle layer is the thickest part of the cornea, mostly made up of water and a protein called collagen. Collagen makes the cornea strong and flexible, and helps keep its regular, round shape. This healthy cornea focuses light so you can see clearly. With keratoconus, the cornea thins and bulges into an irregular cone shape, resulting in vision loss.
Several things may have a link to the condition:
Many keratoconus patients are unaware they have the disease. The earliest symptom is a slight blurring of vision or progressively poor vision that is not easily corrected.
Other symptoms of keratoconus include:
The doctor needs to measure the shape of your cornea. There are different ways, but the most common is called corneal topography. The doctor snaps a photo of your cornea and checks it closely. Children of parents with keratoconus should have one every year starting at age 10.
Treatment of keratoconus focuses on the correction of vision and depends on the stage of the disease.
Current treatment for keratoconus includes glasses in the earliest stages to treat nearsightedness and astigmatism. As keratoconus progresses and worsens, glasses are no longer capable of providing clear vision, and patients need to wear a contact lens, usually a hard contact lens.
Progressive keratoconus can be treated by corneal collagen cross-linking. This one-time, in-office procedure involves the application of a vitamin B solution to the eye, which is then activated by ultraviolet light for about 30 minutes or less. The solution causes new collagen bonds to form, recovering and preserving some of the cornea’s strength and shape.
While the treatment cannot make the cornea entirely normal again, it can keep vision from getting worse and, in some cases, may improve vision. The procedure may require the removal of the thin outer layer of the cornea (epithelium) to allow the riboflavin to penetrate the corneal tissue.
Cross-linking was approved as a treatment for keratoconus by the FDA in April 2016, after clinical trials showed that it stopped or produced a mild reversal in bulging of the cornea within three to 12 months after the procedure.
Corneal ring. With severe keratoconus, a standard contact lens may become too uncomfortable to wear. Intacs are implantable, plastic, C-shaped rings that are used to flatten the surface of the cornea, allowing improved vision. They may also allow a better contact lens fit. The procedure takes about 15 minutes.
Corneal transplant. In a corneal transplant, a donor cornea replaces the patient’s damaged cornea. Corneal transplants are often performed on an outpatient basis and take about an hour to complete. Vision usually remain blurry for about three to six months after the transplant, and medication must be taken to avoid transplant rejection. In almost all cases, glasses or a contact lens are necessary to provide the clearest vision after transplant surgery.
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